4 days old

Cell-based Assay Scientist

South San Francisco, CA 94080
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Job ID: R-112487
Location: South San Francisco, CA, US


You've earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you've worked hard to acquire and the passion you already have. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Cell-based Assay Scientist


What you will do

Let's do this. Let's change the world. In this vital role you will be a part of the Therapeutic Discovery organization joining the Discovery Technologies department in support of Amgen's small molecule drug discovery pipeline.
  • Development and optimization of novel cell-based assays
  • Design, implement, and optimize gene-editing (e.g., CRISPR) that enable development and evaluation of real-time, live, cell-based functional assays supporting therapeutic target screening or lead optimization studies
  • Learn, apply, and incorporate automation solutions during assay development and assay troubleshooting
  • Optimize new methods/techniques to generate reliable and reproducible data promptly


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is an ambitious bench scientist with these qualifications.

Basic Qualifications

Doctorate degree OR Doctorate degree completed OR

Master's degree and 4 years of Scientific experience OR

Bachelor's degree and 6 years of Scientific experience

Preferred Qualifications

  • Ph.D. degree with 1+ years of post-doctoral training or a Master's degree with 4+ years postgraduate experience in cell and/or molecular biology
  • Experience working as part of a multi-disciplinary team in a biopharmaceutical setting
  • Familiar with assay technologies including luminescence, fluorescence and FRET/BRET with experience in the utilization of lab automation across assay development and screening
  • Developing, implementing, and executing novel cell-based screening assays in (384 and/or 1536 well plates) to support early drug discovery research
  • Understanding and implementation of a wide range of cell-based assays and readouts (e.g., TR-FRET, BRET, PCA, AlphaScreen, high content imaging, luminescence and fluorescence-based reporter and/or label-free assays)
  • Development and implementation of novel cellular target engagement or activity assays (e.g., second messenger generation, ion flux, reporter, NanoBit/BRET/Nanoluc, gene activation, cellular imaging)
  • Experience with cell characterization and analytical techniques such as DNA sequencing, qPCR and protein expression as well as expertise with phenotypic and functional characterization of immortalized or primary cells
  • Established capabilities in setting-up and operation of fluorescence/luminescence plate readers (e.g., FLIPR, Envision) and automated liquid handlers (e.g., Bravo, Echo, Tempest) in the development of 384- and/or 1536-well microtiter plate assays
  • Familiarity with software and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire, MODDE pro/DoE, Pipeline Pilot)


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates' professional and personal growth and well-being.
  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
  • Generous Total Rewards Plan-comprising health, finance and wealth, work/life balance, and career benefits-with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.


Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Posted: 2021-02-20 Expires: 2021-03-24

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Cell-based Assay Scientist

South San Francisco, CA 94080

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